ZIA BC 011593 (ZIA) | |||
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Title | Investigation of Epigentic Modifiers in Bladder Cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Agarwal, Piyush | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $44,135 | Project Dates | 10/01/2013 - 00/00/0000 |
Fiscal Year | 2014 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) |
Bladder (100.0%) Urinary System (100.0%) |
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Research Type | |||
Cancer Initiation: Alterations in Chromosomes Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
1. Treat panel of bladder cancer cell lines with panel of epigenetic modifying drugs (HDAC inhibitors, HNMT inhibitors, etc) 2. Evaluate cell proliferation by MTS assay 3. Identify changes in microRNA pre- and post-treatment 4. Perform proteomic analysis of cells pre and post treatment to see if any other changes are noted that can be modified or manipulated. 5. Investigate synergy with HSP90 inhibitors as these drugs can potentiate modifiers of epigentic machinery. This latter aim may be done with Dr. Neckers" |