ZIA CP010150-10401 (ZIA) | |||
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Title | Infections, immunity, and inflammation in cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | A Engels, Eric | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $12,309 | Project Dates | 05/14/2007 - N/A |
Fiscal Year | 2009 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Urinary System (100.0%) | ||
Research Type | |||
Combinations of Localized and Systemic Therapies Surveillance |
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Abstract | |||
Human Papilloma Virus (HPV) infection has been associated with penile cancers in men and is considered the direct cause of cervical cancer in women. Multiple putative factors have been suggested as possible precursors to penile neoplasia, including lack of circumcision, poor genital hygiene, and chronic inflammation due to conditions such as balanitis. The relative infrequency of penile cancers in Western countries, lack of HPV testing in men, and inadequate genital sampling strategies have prevented detailed study of early penile neoplasia in men. With the proposed study, we plan to evaluate these putative precursors, including HPV infection, genital hygiene and the interrelationships of these factors with penile inflammation and penile cancer (historically found at high rates in Uganda). Two trials of male circumcision to prevent HIV transmission in Uganda present the opportunity to study these interrelationships. The goals of this study are to determine whether genital hygiene practices influence foreskin inflammation, and whether hygiene, HIV status, and circumcision status influence HPV persistence and penile neoplasia. This work should lead to improved understanding of factors influencing penile neoplasia and potential approaches to genital cancer prevention, with significant public health implications for both men and women regarding risks of oncogenic HPV infection. |