ZIA CP010125 10486 (ZIA) | |||
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Title | Fernald Medical Monitoring Cohort analysis of thyroid disease | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Kilfoy, Briseis | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $35,764 | Project Dates | 07/22/2009 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Thyroid (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
This study is a longitudinal analysis of the association between nitrate and nitrite intake and thyroid conditions and TSH levels in the Fernald Medical Monitoring Program in Southwestern Ohio. Chronic TSH stimulation of the thyroid is hypothesized to result in thyroid cancer. The medical monitoring program and epidemiological study is the result of a settlement between the U.S. Department of Energy and attorneys representing individuals living or working within five miles of the Fernald uranium processing plant between 1952 and 1984. As a result of the monitoring program, longitudinal TSH measurements (minimum 4 measures per person) are available for adults based on five exam cycles between 1998 and 2008. The analysis will model the repeated measurements of TSH levels and thyroid conditions in relation to estimated nitrate ingestion over the follow-up period and adjust for demographic, behavioral, and other risk factors that have been related to both TSH or thyroid conditions and nitrate intake. Nitrate and nitrite exposure will be estimated for the public and private well water systems in the study areas as well as using a food frequency questionnaire and a database on the nitrate and nitrite content of foods. |