ZIA CP010136-10669 (Z1A) | |||
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Title | A pooled investigation of adiponectin and multiple myeloma | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hofmann, Jonathan | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $28,092 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2016 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
N/A | ||
Research Type | |||
Cancer-Related Biology
Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
It has been hypothesized that the observed excess risk of multiple myeloma (MM) among obese individuals could be due to altered circulating levels of adiponectin, a polypeptide hormone with anti-inflammatory properties secreted by adipose tissue. In a recent prospective investigation in PLCO, we observed inverse associations with MM for both total and high-molecular-weight (HMW) adiponectin. The results of this study, to our knowledge the first prospective investigation of circulating adiponectin and MM, suggest that this hormone may play a role in obesity-related myelomagenesis. Replication of this finding in other prospective cohorts is critical. We are currently conducting a pooled nested case-control study of MM risk in relation to total and HMW adiponectin using prospectively collected blood samples from cohorts participating in the NCI Cohort Consortium." |