ZIA CP010121-02138 (Z1A) | |||
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Title | Lymphocyte alterations in pesticide applicators exposed to 2,4-D | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Beane Freeman, Laura | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $13,247 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2016 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Non Hodgkins Lymphoma (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Epidemiologic data suggest that use of the herbicide 2,4-dichlorophenoxyacetic acid (2, 4-D) is associated with non-Hodgkin?s lymphoma and possibly soft tissue sarcoma in exposed human populations. However, the plausibility of this association has been questioned since more than ninety percent of 2,4-D is excreted unchanged, and 2,4-D?s genotoxicity, and carcinogenicity in animals is equivocal. In order to address the biologic plausibility of the epidemiologic findings, we are studying the impact of 2,4-D exposure on lymphocytes, the target cell for Non-Hodgkin?s lymphoma, in a heavily exposed population of pesticide applicators in Kansas. We have obtained biological samples from thirty pesticide applicators with exclusive exposure to 2,4-D at the beginning of the application season, and again, eight to 12 weeks later, to evaluate changes in chromosomal aberration, micronuclei and somatic cell mutation rates, and in DNA repair and immune function. One paper on micronuclei and cell proliferation has been published. Other analyses are underway." |