ZIA CP000185-10678 (Z1A) | |||
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Title | NHANES Oral Microbiome | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Abnet, Christian | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $72,549 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2016 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
N/A | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Technology Development and/or Marker Discovery |
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Abstract | |||
Tobacco use is known to be a primary cause of periodontal disease and may adversely affect oral health in other ways. Tobacco use is also known to alter the bacterial biota of the mouth. These changes may lead directly and indirectly to other adverse health consequences that have previously been associated with periodontal disease, such as heart disease, diabetes, and some cancers. Our specific aims are: 1. Characterize the association between tobacco and oral health in 11,000 subjects in the 2009-2012 NHANES study, a nationally representative sample of the U.S. population with oversampling of persons 60 and older, African Americans, Asian-Americans, and Hispanics and extensive exposure and health information. 2. Investigate the association between types of tobacco use and the oral microbiome in all 11,000 NHANES subjects 3. Investigate the association between the oral microbiome and tobacco-related diseases including periodontitis, cardiovascular and respiratory disease, diabetes, and others in NHANES and investigate the degree to which the oral microbiome mediates the adverse health effects of tobacco use" |