ZIA CP004410-08065 (Z1A) | |||
---|---|---|---|
Title | Cancer Risk in Xeroderma Pigmentosum Heterozygotes | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Goldstein, Alisa | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $1,344 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2016 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Childhood Cancers (50.0%) |
Melanoma (30.0%) | ||
Research Type | |||
Cancer-Related Biology
Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
|||
Abstract | |||
Study of Cancer Risk in Xeroderma Pigmentosum (XP) Heterozygotes: Although XP is a rare recessive genetic condition, carriers of the XP gene mutations are relatively common (about 1 in 500 in the U.S.). This important project is designed to assess the risk of cancer among clinically normal appearing persons who are heterozygous carriers of mutations in one of the XP genes. This project is now in the data gathering phase; about 10 XP families have been registered in the study and completed epidemiological questionnaires have been received from several members of these extended families. We are in the process of registering more XP families in the study and recruiting more individuals from all registered families." |