ZIA BC 011707 (ZIA) | |||
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Title | The effect of therapeutics on mutated IDH1 cell lines and mice tumor models | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Larion, Mioara | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $84,757 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2016 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) |
Brain (100.0%) Nervous System (100.0%) |
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Research Type | |||
Localized Therapies - Discovery and Development Development and Characterization of Model Systems |
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Abstract | |||
Using the methods described above, we have identified 2 IDH-mutated cell lines that are producing the expected phenotype and will be used for further investigations. The cells behave as expected in terms of D-2HG production and the response to different therapeutics will be determined in the future. We have found decreased NAD+ upon treatment with one drug that leads to 80% cell death and we want to pursue this in preclinical models in the future. We have also found that Histone H3 methylation does not change significantly compared with the control cells. |