ZIA CP000185-10779 (ZIA) | |||
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Title | NCI UNC Project ESCC | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Abnet, Christian | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $253,239 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Esophagus (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Population-based Behavioral Factors |
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Abstract | |||
"Background: Esophageal cancer causes an estimated 400,000 deaths per year and ranks as the sixth leading cause of cancer death worldwide, just after breast cancer. Esophageal squamous cell carcinoma (ESCC) accounts for 89% of all esophageal cancer cases worldwide and many of the cases originate in two high risk regions, one in Asia and the other in Africa. Smoking tobacco and heavy alcohol consumption do not explain the incidence rates in the high-risk regions. It is therefore important to consider a wide range of etiologic factors to explain the high rates of cancer in these populations. Malawi has the highest incidence rates of ESCC in Africa. Our previous studies in Kenya and preliminary studies in Malawi point to a number of potential ESCC risk factors. Objectives: Our study aims to enhance our understanding of the causes and outcomes for ESCC in Malawi Eligibility: All suspected ESCC cases will be eligible for enrollment. Design: We will conduct a case-control study of ESCC at Kamuzu Central Hospital, recruiting 300 ESCC cases and 300 controls, to (1) evaluate exposures (including consumption of very hot beverages, use of firewood as fuel, tooth loss and animal exposure) which may influence risk of ESCC in Malawi and (2) collect biological samples to quantify exposures of interest (included in the current proposal) and to study the genetics and genomics of ESCC tumors (to be included in a future proposal)." |