ZIA CP010190-10508 (ZIA) | |||
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Title | Transplant Outcomes in Aplastic Anemia | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Gadalla, Shahinaz | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $64,370 | Project Dates | 00/00/0000 - 00/00/0000 |
Fiscal Year | 2017 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Bone Marrow Transplantation (100.0%) Cancer (100.0%) |
N/A | ||
Research Type | |||
Normal Functioning Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
"""This study aims at identifying molecular markers associated with improved survival after hematopoietic stem cell transplant (HSCT) in patients with severe aplastic anemia (SAA). In collaboration with the National Marrow Donor Program (NMDP) and the Center for International Blood and Marrow Transplant Research (CIBMTR), we measured pre-transplant telomere length (TL) for 700 recipient-donor pairs using the high throughput qPCR assay, and conducted whole exome sequencing and genotype analysis for all recipients, allowing for integrated molecular approaches in understanding disease etiology and outcomes. Our analysis evaluating the role of TL on HSCT outcomes in a set of 330 SAA patients found no association between recipient TL and post HSCT survival, neutrophil recovery, or graft versus host disease. On the other hand, donor TL was a significant predictor for patient survival (JAMA, 2015; 594-602). """ |