ZID BC 011729 (ZID) | |||
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Title | Chronic graft-versus-host disease in children and young adults | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Buxbaum, Nataliya | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $10,952 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Bone Marrow Transplantation (70.0%) Cancer (100.0%) Cancer Survivorship (50.0%) Childhood Cancers (30.0%) |
Childhood Leukemia (30.0%) Leukemia (30.0%) Lung (5.0%) |
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Research Type | |||
Systemic Therapies - Clinical Applications Resources and Infrastructure Related to Cancer Control, Survivorship, and Outcomes Research |
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Abstract | |||
I have been evaluating pediatric patients with cGVHD and providing recommendations on treatment options to their managing/referring physicians. Previously, I co-authored a book chapter on pediatric cGVHD for a patient-education book. In addition, I established a collaboration with pediatric endocrinology to further characterize frequent co-morbidities and late effects encountered in this patient population. Our findings were published this year. Furthermore, insight gained from the bedside has provided experimental questions for my laboratory investigations, which center on chronic graft-versus-host disease. Pre-clinical models inform us on cGVHD biology by allowing evaluation of immune cells in target and lymphoid organs, which are not amenable to investigation in the clinical setting. |