ZIA BC 011798 (ZIA) | |||
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Title | Identification of genomic regulatory elements in pancreas cells | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Arda, Hatice | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $800,611 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Diabetes (50.0%) Digestive Diseases (100.0%) |
Pancreas (100.0%) | ||
Research Type | |||
Normal Functioning Cancer Initiation: Alterations in Chromosomes |
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Abstract | |||
Using cutting-edge genomic technologies, we have mapped and categorized thousands of genomic elements that are putative regulators of pancreas cell lineages. We identified chromatin regions that are associated with cell type-specific gene expression. Our work has revealed an enhancer logic that suggests a mechanisms for the diversification of pancreas cell lineages during development. Our results also revealed previously unrecognized links between endocrine and exocrine pancreas in diabetes risk. |