ZIA BC 011725 (ZIA) | |||
---|---|---|---|
Title | Metabolic basis of chronic graft-versus-host disease | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Buxbaum, Nataliya | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $32,855 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Bone Marrow Transplantation (100.0%) Cancer (100.0%) Nuclear Magnetic Resonance Imaging (NMR) (30.0%) |
N/A | ||
Research Type | |||
Technology Development and/or Marker Discovery Resources and Infrastructure Related to Detection, Diagnosis, or Prognosis |
|||
Abstract | |||
We completed a prospective metabolic pathway utilization screen in the pre-clinical model of cGVHD. This was accomplished through mass spectrometry studies. Having identified several key metabolites perturbed in cGVHD, we employed hyperpolarized metabolites for imaging in the pre-clinical model. We completed RNA sequencing of T cell subsets in the pre-clinical model, which confirmed metabolic perturbations observed in the prospective metabolic screening. We have begun therapeutically targeting the identified pathways in the pre-clinical GVHD model. Metabolic imaging of patients undergoing hematopoietic stem cell transplantation is planned. Testing of metabolic drugs to treat patients with cGVHD is planned. |