ZIA BC 011727 (ZIA) | |||
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Title | In vivo cell kinetics and imaging of chronic graft-versus-host-disease | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Buxbaum, Nataliya | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $32,855 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Bone Marrow Transplantation (100.0%) Cancer (100.0%) Nuclear Magnetic Resonance Imaging (NMR) (50.0%) |
N/A | ||
Research Type | |||
Technology and/or Marker Testing in a Clinical Setting Localized Therapies - Discovery and Development |
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Abstract | |||
We first characterized immune subsets in lymphoid and target organs within the cGVHD pre-clinical model. We then completed in vivo cell kinetics experiments in the said model, and identified differential patterns for cGVHD versus control cohorts. We, then, developed a non-radioactive imaging modality for cGVHD. So far, we have been able to image cGVHD-affected organs in the pre-clinical setting, and our current efforts are directed towards testing this imaging approach for patients undergoing hematopoietic stem cell transplantation with and without resultant immune dysregulation. |