ZIA CP010132 10661 (ZIA) | |||
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Title | I-131 in utero and thyroid disease (Ukraine) | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Cahoon, Elizabeth | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $24,277 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Thyroid (100.0%) | ||
Research Type | |||
Cancer Initiation: Alterations in Chromosomes Resources and Infrastructure Related to Etiology |
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Abstract | |||
The study was designed to evaluate risk of thyroid cancer and other adverse outcomes following prenatal exposure to Iodine-131 in radioactive releases from the April 1986 Chernobyl nuclear accident. The study population is a well-defined cohort of 2,582 mother-child pairs from contaminated areas of northern Ukraine, originally assembled to investigate the risk of benign and malignant thyroid disease through an in-depth clinical screening examination of the offspring and structured interviews with the mothers carried out in 2003-2006. Individual estimates of fetal thyroid Iodine-131 dose are available for all subjects. Results of thyroid disease risk analyses based on the cycle 1 screening were published in 2009 (J Clin Endocrinol Metab). In a subsequent effort, we ascertained data on reproductive outcomes by retrieving and reviewing cohort members' prenatal, delivery and newborn records. Statistical analyses to examine the relationship of prenatal I-131 dose with neonatal anthropometrics were carried out, and the results showing dose-dependent relationships with head and chest circumference were published in 2017 (Eur J Epidemiol). A second ultrasound screening examination of the offspring was carried out in 2012-2015. A manuscript is in preparation summarizing the updated findings for thyroid cancer at cycles 1 and 2 as well as for I-131 risk of benign thyroid nodules at cycle 2. We are currently exploring radiation effects on reproductive function/fertility among the in-utero exposed offspring based on a 2016 questionnaire survey with both female and male cohort members. |