ZIA CP010126 10465 (ZIA) | |||
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Title | Komen Tissue bank | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Benson, Gretchen | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $27,947 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
Invasive breast cancers are believed to arise from normal breast structures specifically, the potential milk secreting units called terminal duct lobular units (TDLU). The last decade of breast cancer research has resulted in several established breast cancer risk factors, yet the biological mechanisms and markers associated with these risk factors remain poorly defined. We hypothesize that altered histomorphology in TDLUs, levels of proliferation, levels of apoptosis, and levels of the ER and PR in TDLUs, may be associated with known breast cancer risk factors. Previous efforts to characterize mechanisms of carcinogenesis for known risk factors have been limited by small sample sizes and incomplete epidemiologic characterization of the subjects. We are collaborating with the Susan G. KomenŽ for the Cure Tissue Bank at the IU Simon Cancer Center (KTB), which offers a rich and unique opportunity for identifying links between biologic markers and breast cancer risk factors. This repository includes questionnaire data, breast tissue, saliva, serum, and whole blood collected from over 1000 healthy women volunteers that exhibited no evidence of breast cancer. The current project offers the possibility of determining the mechanisms by which risk factors act on epithelial cells prior to tumor development. |