ZIA CP010126 10555 (ZIA) | |||
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Title | Ultrasound Tomography | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Benson, Gretchen | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $25,880 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Aging (20.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Cancer-Related Biology
Resources and Infrastructure Related to Prevention |
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Abstract | |||
We hypothesize that breast density represents a ?biosensor? of tamoxifen response, reflecting bioavailability and action of active drug metabolites. Distinguishing tamoxifen responders from non-responders at the earliest time point would have value for making informed treatment decisions, providing a rationale for continued therapy among responders while sparing non-responders exposure to ineffective treatment. We are using a novel ultrasound tomography (UST) scanner to repeatedly assess volumetric breast density within the first year of tamoxifen for up to 150 women with a referral from a health professional based on a personal risk of breast cancer or a diagnosis of atypical lobular or ductal hyperplasia (ALH/ADH), ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS), or invasive breast cancer to assess whether tamoxifen-related declines in mammographic density found at 12 months can be identified earlier with UST. UST is ideally suited for this application because it produces volumetric data and avoids artifacts secondary to breast compression and exposure to potentially harmful ionizing radiation. For comparison, we will perform UST on a group of 150 age-, race-, and menopausal status-matched women without breast cancer in order to assess changes in UST density over time without tamoxifen exposure. The specific goal of this project is to utilize UST to describe the early time course of volumetric breast density change. The broader objective is to assess the concept of breast density as a biosensor of tamoxifen response and UST as a useful tool for making this determination. |