ZIA CP010221 10405 (ZIA) | |||
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Title | SELECT and Prostate Cancer Prevention Trial (PCPT) | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Albanes, Demetrius | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $19,710 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Prostate (100.0%) | ||
Research Type | |||
Dietary Interventions to Reduce Cancer Risk and Nutritional Science in Cancer Prevention Chemoprevention |
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Abstract | |||
The SELECT trial tested supplementation with vitamin E and selenium for prevention of prostate cancer. Research is aimed at explaining the difference in outcome compared to ATBC and NPC trials, and overall to determine environmental and genetic causes of prostate cancer. The Biology of PCPT is testing a range of hypotheses in the context of a finasteride intervention trial cohort. Nutritional exposures are believed to contribute to the many human cancers although most of the specific causal factors have not been definitively identified. Since diet is a universal and modifiable exposure, research in this area offers the opportunity of significantly reducing cancer incidence and mortality. The Metabolomic Epidemiology Branch conducts independent and collaborative research on the role of metabolism, vitamins and nutritional status in cancer etiology. The Branch seeks to generate and test specific nutritional hypotheses, providing a scientific basis for public health recommendations and further understanding of the molecular basis of carcinogenesis. Our recent analysis in SELECT looked at serum vitamin E and found an interaction with the trial selenomethionine supplement. |