ZIA CP010120 10815 (ZIA) | |||
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Title | The interrelationship between airborne particulates, genomic resilience, and c | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Lan, Qing | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $94,065 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
N/A | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
In the UK Biobank of 500,000 representative adult participants from the United Kingdom, we propose to: 1a) Evaluate the associations between self-reported occupational exposure to diesel exhaust and risk of multiple cancers including those of the lung, bladder, kidney, lymphoid and hematopoietic tissue, gastrointestinal system, prostate, breast, and ovaries. 1b) Evaluate the associations between self-reported occupational exposure to diesel exhaust and risk of all-cause and cancer-specific mortality. 1c) Evaluate the associations between self-reported occupational exposure to diesel exhaust and biological markers including leukocyte telomere length (LTL), blood cell counts, and white blood cell (WBC) subtype differentials. 2a) Evaluate the associations between residential exposure estimates of PM10, PM2.5, and NO2 and risk of multiple cancers including those of the lung, bladder, kidney, lymphoid and hematopoietic tissue, gastrointestinal system, prostate, breast, and ovaries. 2b) Evaluate the associations between residential exposure to estimates of PM10, PM2.5, and NO2 and risk of all-cause and cancer-specific mortality. 2c) Evaluate the associations between residential exposure estimates of PM10, PM2.5, and NO2, and biological markers including LTL, blood cell counts, and WBC subtype differentials. |