ZIA CP010193 10392 (ZIA) | |||
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Title | PanScan - Genome Wide Scan of Pancreatic Cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Solomon, Rachael | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $297,669 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Diabetes (5.0%) Smoking Behavior (10.0%) |
Pancreas (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Within the framework of the NCI-sponsored Cohort Consortium, investigators from 12 prospective epidemiologic cohorts formed the Pancreatic Cancer Cohort Consortium in 2006. The group?s study, also known as ?PanScan?, was funded by the National Cancer Institute (NCI) and involves a genome-wide association study (GWAS) of common genetic variants to identify markers of susceptibility to pancreatic cancer. In 2007, the study was expanded to include 8 case-control studies. The study team includes scientists from the cohorts comprising the Consortium and NCI. PanScan 1, 2 were conducted in 12 cohort studies and 8 case-control studies, leading to the discovery of four novel regions in the genome associated with risk for pancreatic adenocarcinoma. A third phase of PanScan was conducted using more recently identified incident pancreatic cancer cases drawn from fourteen cohorts from the cohort consortium, including nine prospective cohorts who participated in PanScan I, and five newly joined cohorts and cases from a case series and two case control studies with previously genotyped controls. The new GWAS identified an additional 5 new loci associated with pancreatic adenocarcinoma. The genotype results and executive summaries of individual SNP analyses have been made publicly available on dbGap. |