ZIA CP010168 10491 (ZIA) | |||
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Title | The Abby Project: Adolescence among Bangladeshi and British youth | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Troisi, Rebecca | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $51,753 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast (100.0%) | ||
Research Type | |||
Cancer-Related Biology
Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
There has been little research on the role of adrenarche (puberty of the adrenal gland) in influencing levels of reproductive hormones. This cross-sectional project will, therefore, explore adrenarche as a critical period affecting reproductive hormone levels and will explore the potential links to breast cancer risk. Healthy girls (n=700) aged 5-16 will be recruited from 4 populations: 1) Bangladeshi sedentees still living in Sylhet, Bangladesh, 2) Bangladeshi 1st generation migrants to Britain, 3) 2nd generation Bangladeshis in Britain 4) British residents in similar communities. These populations were chosen because the developmental environment in Bangladesh differs greatly from that in the UK specifically with regard to economic factors, access to health services and exposure to infectious diseases. The study will assess androgen levels, primarily dehydroepiandrosterone sulphate (DHEA-S), in relation to chronological age, age at migration, and time since migration. To determine populational differences in timing of adrenarche, the effects of immunological stressors, body shape, diet and exercise will be explored. We hypothesize that androgens will be lower and will rise at a later age in Bangladeshi sedentees and older migrant girls due to the immunological stressors experienced in Bangladesh. Study results could have public health implications for migrant populations concerning earlier puberty and elevated breast cancer risk. |