ZIA CP010126 03050 (ZIA) | |||
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Title | Endometrial cancer epidemiologic study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hoover, Robert | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $3,273 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Basic Behavioral and Social Science (100.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Behavioral and Social Science (100.0%) |
Uterine (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
A multi-center case-control study of endometrial cancer evaluated the relationships with estrogen replacement therapy, cigarette smoking, alcohol consumption, anthropometric factors, dietary factors, physical activity, and use of oral contraceptives. We found that menopausal estrogen increased risk, but combination estrogen-progestin use was associated with a lower risk of endometrial cancer than estrogen use alone. Cigarette smokers, primarily current smokers, were found to be at reduced of endometrial cancer. Alcohol consumption was inversely related to risk, particularly among younger women. Upper body obesity was directly related to risk in a dose-response relationship. Inactivity was associated with increased risk. Analyses of dietary data revealed an increase in endometrial cancer with higher intakes of fat and a decrease with intake of complex carbohydrates. While the main analyses of data from this study have been completed, this study continues to be a valuable resource for contributing data to a variety of consortial analyses, including the Oxford Collaborative Analysis and the Epidemiology of Endometrial Cancer Consortium (E2C2). |