ZIA CP005782 10666 (ZIA) | |||
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Title | Studies of Hepatitis D Virus | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | O'Brien, Thomas | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $47,801 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Liver Cancer (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
We study the prevalence of hepatis D virus (HDV) and its association with disease in the Gambia Liver Cancer (GLC) Study and other cohorts. GLC was conducted in conjunction with The Gambia Hepatitis Intervention Study, an international collaborative project designed to evaluate the efficacy of phased introduction of hepatitis B vaccine into The Gambia?s national immunization program in preventing chronic HBV infection, chronic liver disease, and hepatocellular carcinoma (HCC). The GLCS recruited subjects from September 1997 through January 2001 to determine the fraction of HCC resulting from HBV, HCV, or aflatoxin before any significant influence from nationwide HB vaccination. The subjects were recruited from liver-disease referral clinics at each of The Gambia?s three tertiary care hospitals (Royal Victoria Hospital [RVH], Banjul; Medical Research Council Hospital [MRC], Fajara; and Bansang Hospital [BSG], Bansang). |