ZIA CP000185 10361 (ZIA) | |||
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Title | The Golestan Cohort Study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Abnet, Christian | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $65,336 | Project Dates | null - null |
Fiscal Year | 2018 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Digestive Diseases (100.0%) |
Esophagus (60.0%) Liver Cancer (10.0%) Stomach (30.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
This cohort study will evaluate environmental and genetic risk factors for esophageal squamous cell carcinoma (ESCC) in Golestan Province, Iran. Age standardized ESCC incidence rates of 109/100,000 in men and 175/100,000 in women were reported from this area in the 1970s, and no studies have been performed since that time. A case-control study was recently completed as a collaboration between DCEG and the Digestive Diseases Research Center (DDRC) of Tehran University of Medical Sciences. This cohort study is a collaboration between DCEG, DDRC, and the International Agency for Research on Cancer (IARC) in Lyon. Between 2004 and 2008 the study recruited 50,000 adults in three administrative districts of eastern Golestan Province. Baseline assessments included a lifestyle questionnaire, a semi-quantitative food frequency questionnaire, and collection of blood, hair, nails and urine. Annual follow-up is ongoing, and includes active surveillance by a study team, aided by a comprehensive health network in the rural areas, a GI referral clinic in the largest town, and a provincial cancer registry. The main hypotheses include dietary hypotheses (low consumption of fruits and vegetables, high consumption of hot tea), exposure to potential carcinogens (tobacco, PAHs from non-tobacco sources), novel exposures (opium, animal contact), and genetic susceptibility. |