Z01 BC 010594 (Z01) | |||
---|---|---|---|
Title | Molecular Mechanisms of Drugs | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Khan, Javed | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $87,588 | Project Dates | 10/01/2004 - N/A |
Fiscal Year | 2007 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
N/A | Neuroblastoma (80.0%) | ||
Research Type | |||
Systemic Therapies - Discovery and Development Systemic Therapies - Clinical Applications |
|||
Abstract | |||
Another area, which we will focus on, is the monitoring of gene expression changes impacted by drugs. The choice and design of many chemotherapeutic agents currently used in cancer treatment has been traditionally empirical in nature. The molecular mechanisms of their actions are not well understood, and their mode of action is often indiscriminate targeting, both of tumor and normal cells. We will identify molecular signature of effect of drugs acting on neuroblastoma. We will screening series of novel drugs to predict how they work based on their gene expression signature. |