Z01 BC 010020 (Z01) | |||
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Title | Clinical Trials with Immunotoxins | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Pastan, Ira | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $455,118 | Project Dates | 10/01/1996 - N/A |
Fiscal Year | 2007 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
N/A |
Leukemia (5.0%) Non Hodgkins Lymphoma (8.0%) Ovarian Cancer (5.0%) Prostate (5.0%) Urinary System (5.0%) |
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Research Type | |||
Vaccines Systemic Therapies - Clinical Applications |
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Abstract | |||
<p>Phase 1 trials with HA22, a new more active form of BL22 have been initiated in CLL and Hairy Cell Leukemia.</p><P>A phase 2 trial with immunotoxin BL22 that targets CD22 on Hairy Cell Leukemia has been completed. 32 patients have been treated and about half of these patients have under gone complete remissions.</P><P>A phase 1 trial with BL22 in pediatric ALL is open in collaboration with Dr. Alan Wayne, P.O.B. The current dose level is 40 microgram/kg Q.O.D. x 6. No major toxicities have occurred and anti-tumor activity has been observed.</P><P>Two phase 1 trials with immunotoxin SS1P given by continuous infusion or Q.O.D. x 3 for mesothelioma, pancreatic cancer and ovarian cancer have been completed. Several minor responses were observed. A phase 2 trial combining SS1P with chemotherapy is planned to open in late 2007.</P><P>A phase 1 trial in CLL with immunotoxin LMB 2 targeting CD25 is open. Also a phase 1 trial in CTCL is open.</P> |