Z01 BC 010669 (Z01) | |||
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Title | Role of Gene Methylation in Tumor Microenvironment | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Woodson, Karen | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $96,889 | Project Dates | 10/01/2005 - 08/31/2007 |
Fiscal Year | 2007 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
N/A |
Prostate (100.0%) Urinary System (100.0%) |
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Research Type | |||
Cancer Progression and Metastasis Technology Development and/or Marker Discovery |
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Abstract | |||
We recently discovered that aberrant gene methylation occurs in the stroma and endothelium adjacent to tumor epithelium in prostate cancer patients. This suggests that epigenetic changes such as gene hypermethylation may play a role in the tumor microenvironment. These findings have implications for prostate cancer diagnosis and therpeutic interventions. To pursue these studies, we will conduct an exhaustive examination of promoter methyltion of several genes important in prostate carcinogenesis. Gene methylation profiles in stroma surrounding tumor epitehlium as compared to the tumor itself will be examined. |