Z01 BC 008396 (Z01) | |||
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Title | Molecular Information Theory | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Schneider, Thomas | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $557,341 | Project Dates | 10/01/1988 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Digestive Diseases (50.0%) Genetic Testing (100.0%) |
Colon/Rectum (48.0%) Skin (48.0%) Stomach (2.0%) |
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Research Type | |||
Resources and Infrastructure Application of Model Systems |
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Abstract | |||
A set of important papers were completed that demonstrate the power, elegance and usefulness of information theory for a variety of molecular systems: We discovered a number of p53, p63 and p73 genes; We analyzed splice site mutations in Xeroderma Pigmentosum variant patients; We characterized sigma 70 promoters in E. coli; We discovered clusters of Fur binding sites in E. coli; We determined the relationship between DNA protein binding on- and off- rates with information of the binding site. This revealed the evidence that DNA binding is a coded function instead of a simple chemical reaction. Further details can be found in the papers, all of which are availabe from <a href = "http://www.ccrnp.ncifcrf.gov/~toms/" >http://www.ccrnp.ncifcrf.gov/~toms/</a> <BR><BR> Z01 BC 08396-14 |