ZIABC011452 (ZIA) | |||
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Title | Synthesis of Anti-Alzheimer's Oligomeric Compounds | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Schneekloth, John | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $89,000 | Project Dates | 10/01/2011 - N/A |
Fiscal Year | 2012 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Aging (100.0%) Cancer (100.0%) |
Brain (100.0%) Nervous System (100.0%) |
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Research Type | |||
Chemoprevention Application of Model Systems |
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Abstract | |||
In an effort to identify small molecules with anti-Alzheimer's potential, we recently carried out a screen for molecules that disrupt the binding of abeta to receptor-expressing cells. A hit molecule from this screen was revealed to be an oligomeric degradation product of a known molecule. The specific structure of this oligomeric degradation product has been elusive: it appears to be polydispersed and may not be a single structure. However, extensive biochemical and animal studies revealed that it has significant potential as a therapeutic. Our efforts to date have revolved around generating synthetic material that mimics the behavior of the degradation product, and studying structure-activity relationships of this fascinating molecule. In collaboration with Stephen Strittmatter (Yale University) we have used a variety of analytical and synthetic techniques to further characterize the compound |