Z01 CP010133-04018 (Z01) | |||
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Title | Leukemia risk in Baltic clean-up workers | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Linet, Martha | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $11,061 | Project Dates | 03/01/1992 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Head and Neck (20.0%) Leukemia (80.0%) Thyroid (20.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Surveillance |
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Abstract | |||
In a study of cancer incidence among 10,332 Chernobyl clean-up workers from Estonia and Latvia followed from 1986 to 1998, we did not observe a significantly elevated risk of leukemia (O/E=1.53; 95% CI:0.62-3.17; O=7) or of all cancers combined (O/E=1.15; 95% CI: 0.98-1.34). Thyroid cancer (O/E=7.06; 95% CI: 2.84-14.55; O=7) and brain cancer (O/E=2.14; 95% CI: 1.07-3.83; O=11) were increased, based primarily on the Latvian data. There was no evidence of dose-response for any of these sites, and the relationship to radiation exposure remains to be determined.. The excess for thyroid cancer appeared to be due largely to screening; the leukemia cases included two unconfirmed diagnoses, and the excess of brain cancer might have been a chance finding. There was an indication of increased risk associated with early entry to the Chernobyl area and late follow-up, though not statistically significant. Further follow-up of Chernobyl clean-up workers is warranted to clarify the possible health effects of their radiation exposures. |