ZIA CP010190-10508 (ZIA) | |||
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Title | Telomere length after HSCT in patients with acquired severe aplastic anemia | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Savage, Sharon | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $161,832 | Project Dates | 01/01/2009 - N/A |
Fiscal Year | 2012 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Bone Marrow Transplantation (100.0%) Cancer (100.0%) |
N/A | ||
Research Type | |||
Normal Functioning Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
This study will evaluate the role of blood cell telomere length in outcomes after hematopoietic stem cell transplant (HSCT) in patients with acquired severe aplastic anemia (SAA). In collaboration with the National Marrow Donor Program (NMDP) and the Center for International Blood and Marrow transplant research (CIBMTR), we have measured pre-transplant TL in both donors and recipients using QPCR, and will evaluate its role in outcomes including death, post-transplant malignancies, and fibrotic diseases. TL has also been determined on 300 healthy individuals and 40 patients with dyskeratosis congenita (DC) to use as a reference population for normal and very short telomeres, respectively. The data is currently being analyzed. We will also sequence genes associated with DC in the cases and controls in order to determine the incidence of occult DC in this population. |