Z01 CP010183-10316 (Z01) | |||
---|---|---|---|
Title | SEER Special Studies | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Anderson, William | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $62,934 | Project Dates | 06/21/2005 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Breast Cancer (60.0%) Ovarian Cancer (40.0%) |
||
Research Type | |||
Cancer Related Biology Surveillance |
|||
Abstract | |||
Seer special study: Accumulating molecular biologic data demonstrate that the stratification of tumors by gene expression profiles, immunohistochemical (IHC) staining patterns, as well as other techniques may permit the categorization of breast cancers into distinct biological groups. These results, however, have not been validated in the general population. Our objective is to obtain a population-based sample of annotated U.S. breast cancer tissues through collaboration with the SEER Tissue Discard Registries in Iowa, Los Angeles, and Hawaii, and to use these materials to build tissue microarrays (TMAs). Using appropriate sampling techniques, we will extrapolate results from our sample to the entire U.S. population. Completion of this work will validate discovery-based molecular portraits for different breast cancer subtypes such as luminal, basal, and HER2 phenotypes, providing insights for breast cancer etiology, surveillance, prevention, and treatment. |