Z01 CP010190-10371 (Z01) | |||
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Title | Telomere length, cancer risk, and genetic determinants | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Savage, Sharon | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $186,201 | Project Dates | 05/01/2006 - N/A |
Fiscal Year | 2008 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Aging (50.0%) Biochemical Epidemiology (45.0%) Cancer (100.0%) Childhood Cancers (10.0%) |
Ovarian Cancer (30.0%) Prostate (50.0%) Sarcoma (20.0%) Sarcoma, Bone (Sarcoma Subset) (20.0%) |
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Research Type | |||
Cancer Related Biology Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
This study will identify genetic determinants of telomere length in healthy individuals and determine if telomere length is a risk factor for cancer. The genetic variants that correlate with telomere length will be evaluated utilizing data derived from the NCI CGEMS genome-wide association studies of prostate and breast cancer. Telomere length was measured by Q-PCR in prostate cancer cases and controls from the PLCO cohort. A genome-wide association study was performed on these same individuals in the CGEMS project. In parallel, our collaborators at Harvard studied breast cancer cases and controls. A statistically significant association between prostate cancer risk and telomere length was not identified, but associations were found between telomere length and healthy lifestyle parameters. The analyses correlating genome-wide polymorphism data with telomere length in these subjects are underway. Telomere length has been determined in both ovarian cancer cases and controls and in osteosarcoma cases and controls. These data are being analyzed and if significant associations are identified, further studies will be conducted. |