ZIA CP010125-02130 (ZIA) | |||
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Title | Cancer Risk and Environmental Exposures | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Cantor, Kenneth | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $60,154 | Project Dates | 09/01/1985 - N/A |
Fiscal Year | 2009 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Bladder (17.0%) Brain (17.0%) Colon/Rectum (34.0%) Kidney Cancer (17.0%) Kidney Disease (17.0%) Pancreas (16.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Resources and Infrastructure Related to Etiology |
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Abstract | |||
Previous epidemiological studies have linked various occupations and industries to the risk of pancreatic cancer but the results have been inconsistent. To further examine the relationship between occupational exposures and pancreatic cancer risk in both men and women, we analyzed the data from a population-based case-control study conducted in Iowa involving 376 histologically confirmed incident pancreatic cancer cases and 2,434 controls. A significantly increased risk was observed among men who worked in chemical and allied product industries; railroad transportation industries; trucking and warehousing; elementary and secondary schools. An increased risk was also observed among men employed as truck drivers; railroad brake, signal, and switch operators; purchasing agents and buyers; teachers; insurance sellers; and retail supervisors. Among women, a significantly increased risk of pancreatic cancer was found for employment in furniture and home furnishing stores, and an increased risk of borderline significance was observed among textile sewing machine operators and tenders. In conclusion, our results indicate that occupational exposure may increase the risk of pancreatic cancer and these findings warrant further investigation. |