ZIA CP010195 10436 (ZIA) | |||
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Title | Vitamin D Pooling Project | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Albanes, Demetrius | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $337,546 | Project Dates | 01/01/2008 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Esophagus (9.0%) Kidney Cancer (17.0%) Kidney Disease (17.0%) Non Hodgkins Lymphoma (17.0%) Ovarian Cancer (16.0%) Pancreas (17.0%) Stomach (8.0%) Uterine (16.0%) |
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Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Nutritional Science in Cancer Prevention |
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Abstract | |||
Epidemiologic evidence suggests that vitamin D deficiency is associated with an increased risk of several types of cancers, including colorectal, breast, and prostate cancer. It is unclear, however, whether vitamin D is also associated with the development of other rarer and more lethal cancers, such as renal, gastric and esophageal, ovarian, lymphoma and pancreatic cancers, since few studies have adequate numbers of cases to examine the association. Within the framework of the NCI-sponsored Cohort Consortium, the Vitamin D Pooling Project-Rarer Cancer Consortium was formed to conduct analyses of the associations between serum vitamin D concentrations and the development of rarer cancers. Specifically, we will measure serum 25-hydroxyvitamin D (25(OH)D), considered to be the best indicator of nutritional vitamin D status, in the 9 participating cohorts, and analyze this indicator in relation to six rarer cancer types: pancreatic, ovarian, lymphoma, upper gastrointestinal, endometrial, and renal. This investigation will be conducted with the context of a nested case-control design, for which cases of each type of cancer will be compared to age-, gender-, race- and month/season- matched controls. Findings from this study have the potential to offer a greater understanding of the role of vitamin D in the development of rarer cancers. The specific aims of this study are to: 1) Conduct assays for 25(OH)D on identified cases and matched controls to determine the association between pre-diagnostic 25(OH)D levels and the development of pancreatic, ovarian, lymphoma, upper gastrointestinal, endometrial, and renal cancer; examine regional, latitude, and ethnicity differences in association; and, 2) Conduct pooled analyses of the associations between 25(OH)D and the rarer cancers incorporating any existing data from participating cohorts who have previously analyzed vitamin D and the association with these cancer sites. |