ZIA CP010144 07130 (ZIA) | |||
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Title | Inherited bone marrow failure syndromes study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Alter, Blanche | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $1,589,054 | Project Dates | 10/01/2000 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Bone Marrow Transplantation (10.0%) Cancer (100.0%) Chemoprevention (20.0%) Childhood Cancers (100.0%) |
Breast (2.0%) Buccal Cavity (25.0%) Cervical Cancer (5.0%) Childhood Leukemia (100.0%) Esophagus (5.0%) Leukemia (35.0%) Liver Cancer (5.0%) Lung (1.0%) Pancreas (5.0%) Pharynx (1.0%) Vaginal (5.0%) |
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Research Type | |||
Cancer Related Biology Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
This project is studying families with diverse inherited bone marrow failure syndromes (of which Fanconi's anemia is the prototype) to investigate mechanisms of human susceptibility to leukemia, head/neck cancers and anogenital cancers. We are engaged in gene mapping and cloning, and will study a wide range of clinical, epidemiologic, genetic, behavioral and laboratory features of these syndromes. This project is evaluating the possible role of the human papilloma virus (HPV) as an important risk factor for a number of the solid tumors which occur excessively in these patients. We will be performing genotype/phenotype correlations, and investigating the possibility that heterozygous carriers of the recessive bone marrow failure disorders might be at increased risk of malignancy as well. |