ZIA CP010170 02222 (ZIA) | |||
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Title | Non-Hodgkin's lymphoma pilot study: chemotherapy and blood levels of organochlori | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Baris, Dalsu | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $22,814 | Project Dates | 01/01/1997 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Non Hodgkins Lymphoma (100.0%) | ||
Research Type | |||
Cancer Related Biology Exogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Several small studies suggest a link between environmental exposure to organochlorine compounds and risk of non Hodgkin's lymphoma (NHL). Because NHL is uncommon, studies of the topic often use a population-based case-control design, in which cases generally are enrolled after treatment has begun. If chemotherapy affects blood levels of organochlorines, exposure will be misclassified and findings distorted. To determine whether chemotherapy alters serum levels of organochlorines in NHL cases, we compared serum samples before and after treatment in 22 cases diagnosed with NHL between March 1994 and August 1995 and enrolled in a clinical trial at the United States National Cancer Institute's Clinical Center. The time difference between pretreatment and posttreatment samples ranged from 15 to 27 months with an average of 20 months. Laboratory analyses were conducted in blinded pretreatment and posttreatment pairs of the subjects. Pretreatment and posttreatment organochlorine serum levels were compared using Pearson correlation coefficient (r) and paired t test. |