ZIA CP010121 10363 (ZIA) | |||
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Title | A CROSS-SECTIONAL STUDY OF OCCUPATIONAL EXPOSURE TO TRICHLOROETHYLENE, CHROMOSOMA | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Lan, Qing | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $44,311 | Project Dates | 09/01/2005 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Leukemia (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Trichloroethylene (TCE) is an industrial solvent used in degreasing, dry cleaning, and numerous other medical and industrial processes. It is a ubiquitous environmental contaminant of drinking water and is present in many EPA Superfund sites. TCE is a rodent carcinogen but its carcinogenicity in humans is unclear. There is some evidence for an elevation in liver and kidney cancer and non-Hodgkin¿s lymphoma in epidemiological studies. The carcinogenicity of TCE and its regulation is a matter of continuing debate despite an extensive database of in vitro and in vivo animal studies and several cohort and case-control studies. IARC categorizes TCE as a probable human carcinogen (2A). The OSHA PEL for TCE is 50 ppm (269 mg /m3), based on the avoidance of central nervous system toxicity, with a STEL of 100 ppm (537 mg /m3) in order to address continuing questions about TCE¿s potential carcinogenicity and mechanism of action in humans, we propose to conduct a cross-sectional study of early biologic effect biomarkers in 45 workers exposed to > 25 ppm TCE and 45 unexposed controls in Guangzhou, China. Our primary goal is to determine if TCE exposure is associated with higher levels of specific types of chromosomal aberrations that have been detected in NHL and other hematopoietic malignancies. In addition, we will apply a new generation of cytogenetic and molecular techniques to study TCE¿s potential genotoxicity and immunotoxicity and to evaluate the presence of liver and renal toxicity. This work will compliment previous and ongoing OEEB studies of populations exposed to TCE and has the potential to make an important contribution to what little is known about the early biologic effects of TCE in humans |