ZIA CP010126 10538 (ZIA) | |||
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Title | WHI Hormones and Gynecologic Cancers Study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Brinton, Louise | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $26,342 | Project Dates | 07/01/2010 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Ovarian Cancer (50.0%) Uterine (50.0%) |
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Research Type | |||
Endogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
Endogenous estrogens are recognized as causal agents in the etiologies of breast and endometrial cancers, and may also play a role in ovarian cancer. Studies of postmenopausal women have consistently shown that elevated circulating estrogens and androgens are associated with increased risk of endometrial cancer. Few studies of circulating hormones and risk of ovarian cancer have been conducted, and these have inconclusive findings due to limitations of experimental design and low case numbers. Roles of hormone metabolism and of particular metabolites in cancer risk have not been studied in epidemiologic studies of endometrial or ovarian cancers, in part because of the need for a sensitive, reliable, and high through-put assay. We are proposing a nested case-control study of endometrial and ovarian cancers to assess the roles of estrogens, estrogen metabolites, and androgens in the etiologies of these cancers. Cases and shared controls will be drawn from the Womenęs Health Initiative Observational Study (WHIOS) cohort. Analytes will be measured with a recently developed liquid-chromatography/mass spectrometry (LC-MS) assay that can measure 15 estrogens and estrogen metabolites and four androgens with high sensitivity using limited amounts of serum. The proposed research would benefit from unique WHIOS resources including large numbers of cancer cases, prospectively collected serum and baseline data on important cancer risk factors; we expect that resulting data will be an important contribution to understanding the etiologies of endometrial and ovarian cancers, and of hormone-mediated carcinogenesis. Sharing of controls will make efficient use of WHIOS and laboratory resources. This study will provide a comprehensive assessment of estrogen and androgen exposures in the etiologies of endometrial and ovarian cancers, and will also be the largest prospective study of endogenous sex hormones and risk of these gynecologic caerncers done to date. |