ZIA CP010190 10508 (ZIA) | |||
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Title | Telomere length after HSCT in patients with acquired severe aplastic anemia | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Savage, Sharon | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $45,627 | Project Dates | 10/01/2009 - N/A |
Fiscal Year | 2010 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Bone Marrow Transplantation (100.0%) Cancer (100.0%) |
N/A | ||
Research Type | |||
Normal Functioning Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
This study will evaluate the role of blood cell telomere length in outcomes after hematopoictic stem cell transplant (HSCT) in patients with acquired severe aplastic anemia (SAA). In collaboration with the National Marrow Donor Program (NMDP) and the Center for International Blood and Marrow transplant research (CIBMTR), we will measure pre-transplant TL in both donors and recipients using QPCR, and will evaluate its role in outcomes including death, post-transplant malignancies, and fibrotic diseases. In addition, we will determine telomere length on us 300 healthy individuals and 40 patients with dyskeratosis congenita to use as a reference population for normal and very short telomeres, respectively. |