ZIA BC 011005 (ZIA) | |||
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Title | Isolation and Purification of Cancer Stem Cells Based on Functional Appraoch | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Avital, Itzhak | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $170,206 | Project Dates | 10/01/2007 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Digestive Diseases (40.0%) Organ Transplantation Research (100.0%) |
Breast (50.0%) Liver Cancer (20.0%) Melanoma (10.0%) Pancreas (10.0%) Stomach (10.0%) |
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Research Type | |||
Cancer Progression and Metastasis Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
In this project we investigate wide array of cancers: hepatocellular carcinoma, cholangiocarcinoma, pancreatic adenocarcinoma, breast cancer, melanoma, and gastric cancers This project has two prongs: One, where we use a functional approach to identify the "best" cancer stem cell usiong all previously described methodes and markers and subjecting them to a rigorous tesing methodology. Once identified we will try to target these cells via the specific marker in attempt to generate novel cancer therapy. Two, using a novel methodology we try to isolate the self renwing cells via asymmetric division in various cancers and determine whether these are the "fitest" cancer stem cells |