Title |
UT M.D. Anderson Cancer Center Lymphoma SPORE
|
Institution |
UNIVERSITY OF TEXAS MD ANDERSON CAN CTR, HOUSTON, TX
|
Principal Investigator |
YOUNES, ANAS
|
NCI Program Director |
Peter Ujhazy
|
Cancer Activity |
Translation Research (formerly Organ Systems)
|
Division |
DCTD
|
Funded Amount |
$500,000
|
Project Dates |
09/01/2009 - 08/31/2012
|
Fiscal Year |
2009
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Cancer (100.0%)
Chemotherapy (28.0%)
|
Hodgkins disease (23.0%)
Leukemia (23.0%)
Non Hodgkins Lymphoma (53.0%)
|
Research Type |
Technology and/or Marker Testing in a Clinical Setting
Systemic Therapies - Discovery and Development
Systemic Therapies - Clinical Applications
Resources and Infrastructure Related to Treatment and the prevention of recurrence
|
Abstract |
The University of Texas M. D. Anderson Cancer Center is proposing a Lymphoma Specialized Program of Research Excellence (SPORE). The primary goal of this Lymphoma SPORE is to improve the cure rate of lymphoma through innovative therapeutic strategies based on effective and focused translation of recent discoveries in lymphoma biology, immunology, and molecular genetics. The M. D. Anderson Lymphoma SPORE is a multidisciplinary collaborative effort between basic and translational scientists, clinical investigators, hematopathologists, and biostatisticians that is organized in 4 research projects and 4 core resources, as well as programs for developmental research and career development program.
The research projects listed are designed to target specific areas important in lymphoma:
Project 1 - Epigenetic-based therapy of Hodgkin lymphoma (Liu/Younes)
Project 2 - Development of 8-chloro-adenosine therapy (Gandhi/McLaughlin)
Project 3 - Targeting MDM2/P53 in ALL (Andreeff/O'Brien)
Project 4 - Gene expression profiling and pathway targeted therapy in peripheral T-cell lymphoma
(Chan/Vose)
Core and other resources are the following:
Core A - Administrative
Core B - Biospecimen
Core C - Clinical Research
Core D - Biostatistics and Bioinformatics
Development Research Program (DRP) and Career Development Program (CDP) |