ZIA BC 010483 (ZIA) | |||
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Title | TEM5 Ligand Hunt | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | St. Croix, Brad | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $335,141 | Project Dates | 10/01/2002 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) | Vascular Disease (20.0%) | ||
Research Type | |||
Cancer Progression and Metastasis Systemic Therapies - Discovery and Development |
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Abstract | |||
Tumors are dependent upon new blood vessel formation, or angiogenesis, for expansive growth. Our prior analysis of gene expression in tumor endothelium led to the identification of a G-protein coupled receptor called TEM5. In an attempt to understand the role of TEM5 in angiogenesis and its importance for tumor growth, we previously embarked upon a hunt for its physiological ligand. Through a number of serendipitous events we have now come across what appears to be a ligand for TEM5. We are currently characterizing this factor and its role in tumorigenesis. |