ZIA BC 010549 (ZIA) | |||
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Title | Zebrafish Models of Cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Hickstein, Dennis | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $552,983 | Project Dates | 10/01/2002 - N/A |
Fiscal Year | 2011 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) Childhood Cancers (70.0%) |
Childhood Leukemia (20.0%) Leukemia (20.0%) Ovarian Cancer (20.0%) Sarcoma (60.0%) |
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Research Type | |||
Cancer Initiation: Alterations in Chromosomes Application of Model Systems |
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Abstract | |||
1) Ewing's Sarcoma. Within the preceding year we have shown that zebrafish with EWS/FLI1 leads to mitotic defects with abnormal or multipolar mitotic spindles starting from the bud stage (10hpf). The abnormalities in mitotic spindles were followed by p53-mediated apoptosis in the developing central nervous system (CNS) leading to a reduction in the number of proneural cells, disorganization of neuronal networks, and embryonic lethality by 5 days post-fertilization. 2) Ovarian cancer. We have iidentified zebrafish harboring mutations in the zebrafish BRCA-2 gene. Zebrafish with homozygous mutation of brca2 fail to develop ovaries. However, they develop gonadal tumors over time, a process enhanced with loss of p53. |