Title |
Light Scattering and Normal Tissue Models
|
Institution |
LOS ALAMOS NAT SECTY-LOS ALAMOS NAT LAB, Los Alamos, NM
|
Principal Investigator |
MOURANT, JUDITH
|
NCI Program Director |
Miguel Ossandon
|
Cancer Activity |
Technology Development
|
Division |
DCTD
|
Funded Amount |
$697,307
|
Project Dates |
05/15/1997 - 08/31/2013
|
Fiscal Year |
2012
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Bioengineering (100.0%)
Cancer (100.0%)
Radiation - Non Ionizing - Total (100.0%)
|
Cervical Cancer (100.0%)
|
Research Type |
Technology Development and/or Marker Discovery
Technology and/or Marker Evaluation With Respect to Fundamental Parameters of Method
|
Abstract |
DESCRIPTION (provided by applicant): The general goal of this proposal is to develop non-intrusive optical spectroscopy as a real-time diagnostic technique for cervical dysplasia. In our previous study we have demonstrated good sensitivity and specificity of our fiber-optic probe for diagnosing HSIL in vivo and provided insight into the physical mechanisms which are the basis of our light scattering technique. In this work, we will build on our previous results, by modifying the fiber-optic probe and spectroscopy system to obtain better accuracy, developing a probe for the endocervical canal, studying the false positives and false negatives to understand the causes of inaccuracies, improving our understanding of the physical mechanisms that are the basis for the technique, and finally testing our diagnostic spectroscopic system in the clinic. |