Title |
Targeting Cancer Cells with Functionalized Nanoparticle Libraries
|
Institution |
ALBERT EINSTEIN COL OF MED YESHIVA UNIV, BRONX, NY
|
Principal Investigator |
LEVY, MATTHEW
|
NCI Program Director |
Miguel Ossandon
|
Cancer Activity |
Technology Development
|
Division |
DCTD
|
Funded Amount |
$176,055
|
Project Dates |
08/12/2011 - 07/31/2014
|
Fiscal Year |
2012
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Cancer (100.0%)
|
Prostate (100.0%)
|
Research Type |
Technology Development and/or Marker Discovery
Systemic Therapies - Discovery and Development
|
Abstract |
DESCRIPTION (provided by applicant): We propose to use a combination of two powerful techniques: aptamer selection (systematic evolution of ligands by exponential enrichment; SELEX) and in vitro compartmentalization (IVC), to develop a new method of generating libraries of functionalized nanoparticles and that can be screened directly for function. While the goal of this application is to develop a novel system for the direct identification of targeted nanoparticles which localize to human tumors, we will develop a platform technology which extends beyond the detection and treatment of cancer and other diseases and will result in the generation of a novel class of capture agents that will find use in a variety of applications and fields of research. |