Title |
The Mechanisms of GM-CSF Inhibition of Breast Cancer Growth and Metastasis
|
Institution |
OHIO STATE UNIVERSITY, COLUMBUS, OH
|
Principal Investigator |
EUBANK, TIMOTHY
|
NCI Program Director |
Neeraja Sathyamoorthy
|
Cancer Activity |
Tumor Biology
|
Division |
DCB
|
Funded Amount |
$241,531
|
Project Dates |
09/01/2010 - 08/31/2013
|
Fiscal Year |
2012
|
Project Type |
Grant
|
Research Topics w/ Percent Relevance |
Cancer Types w/ Percent Relevance |
Cancer (100.0%)
Metastasis (100.0%)
|
Breast (100.0%)
|
Research Type |
Cancer Progression and Metastasis
|
Abstract |
PROJECT SUMMARY (See Inslfucllons): The plan for the upcoming ROO phase of the award includes finalization of Specific Aim 2 using the clodronated liposomes as an alternate method for mononuclear phagocyte removal {as discussed In "Changes made to alms'), completion of Specific Aim 3 on the effects of GM-CSF on the growth, angiogenesis, and metastases in human breast cancer in Immunodeficient mice, and further investigation into monocyte and macrophage subpopulations generated in response to GM-CSF treatment. Thus the Specific Aims will address the following questions: Central Hypothesis (modification from original): GM-CSF treatment induces a phenotype switch In tumor infiltrating mononuclear phagocytes and triggers an anti-angiogenic program. Specific Aim 2 (fmm parent gmnt): To determine the cells responsible for sVEGFR-1 production In response to GM-CSF. Specific Aim 3 (from parent grant): Does GM-CSF Inhibit tumor growth, angiogenesis, and metastases of human tumors In nude mice? New Aims based on preliminary data generated from the parent grant and/or collaboration: Specific Aim 4: To determine if GM-CSF changes mononuclear phagocyte cell phenotypes using gene expression signatures and proteomic evaluation. |