ZIA BC 011592 (ZIA) | |||
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Title | Evaluation of Protein Kinase D1 in Bladder Cancer as a Novel Tumor Suppressor | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Agarwal, Piyush | NCI Program Director | N/A |
Cancer Activity | N/A | Division | CCR |
Funded Amount | $114,752 | Project Dates | 10/01/2013 - 00/00/0000 |
Fiscal Year | 2014 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Cancer (100.0%) |
Bladder (100.0%) Urinary System (100.0%) |
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Research Type | |||
Cancer Initiation: Oncogenes and Tumor Suppressor Genes Cancer Progression and Metastasis |
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Abstract | |||
1. Investigate expression of PRKD1 in panel of bladder cancer cell lines for expression by western blotting and PCR 2. Investigate expression of PRKD1 in a tissue microarray of bladder cancer tumor specimens 3. Specifically see if knockdown of this protein can induce more aggressive behavior (greater proliferation and/or invasion and migration). 4. Conversely, investigate whether overexpression in cell lines that lack this gene can arrest growth and/or invasion and migration 5. In vivo experiments to follow pending these results" |