ZIA CP010125 - 10700 (ZIA) | |||
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Title | Ambient Ultrafine Particulate Matter and Cancer Risk | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Silverman, Debra | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $17,316 | Project Dates | 05/27/2014 - 00/00/0000 |
Fiscal Year | 2014 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
N/A | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
This two-phase study within the NIH-AARP Diet and Health Study cohort participants in California will combine the substantial regional variation in particulate matter (PM) concentrations with large numbers of cancers and both smoking and residential histories. Supplemental ambient monitoring will inform historical exposure estimation. We aim to identify determinants of and assess variability in personal ultrafine particulate matter (UFP) exposures, develop a retrospective UFP exposure assessment for the state of California, and assess the association between UFP and cancer risk among cohort participants. Results from the proposed study will improve our understanding of how individuals are exposed to ambient UFP and provide insights into its role in the observed PM-lung cancer association." |