ZIA CP010133 - 10531 (ZIA) | |||
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Title | Thyroid Cancer among Chornobyl Clean-up Workers in Ukraine: Pilot Study | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Mabuchi, Kiyohiko | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $147,689 | Project Dates | 10/01/2010 - 00/00/0000 |
Fiscal Year | 2014 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) |
Thyroid (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Endogenous Factors in the Origin and Cause of Cancer |
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Abstract | |||
Thyroid cancer is known to be caused by exposure to ionizing radiation, but the radiation risk associated with exposure in adult males is not well characterized. We are planning to conduct a case-control study nested in the population of 150,000 male liquidators who participated in the clean-up operation following the Chornobyl accident. In preparation of this study, we are conducting a pilot study of 30-40 thyroid cancer cases and matched controls in this liquidator cohort. Thyroid cases identified from the Ukraine Cancer Registry will be located and interviewed for information needed to estimate thyroid doses and for other factors suspected to be associated with thyroid cancer. Study participants will be asked to provide biological materials for future genetic studies. We will also obtain information on whereabouts of thyroid tumor tissue using various databases." |